Supposedly, at this year's PAX, DN:F was confirmed to be in development by Gearbox software. It's in a playable state, and will be released either the end of this year, or the beginning of 2011. Can't find a great link right now because work blocks gaming sites, but I'll edit one in later. For now you can do your own googling.

Anyway, I'll believe it when I see it. I almost wish it wouldn't come out though. It's just about guaranteed to be a mediocre game, and I'd rather it remain as that mythical "just out of reach" title that it's been for so long.