As far as I know, Colonial America didn't have ancient, towering buildings like Italy did.

I also picture it as more... untamed. Swamp fighting, skulking through the woods, that kind of thing. And there's a lot of chatter that the main character is at least partially American Indian, so that's interesting.

It'll be cool, though I sort of hope they emphasize stealth more, which your post doesn't make me hopeful for.

Most obvious pitfall is to avoid falling into the "AMERICA IS THE LAND OF FREEDOM" trap, which would just be kind of annoying. But judging from the "extras" from the previous games that imply the Templars infiltrated the US gov't long ago, that seems unlikely.