You have to micro-manage your healer in a lot of fights; that's a given. Besides healers, rogues definitely require the most attention, and are the hardest to use to their full potential. Setting everyone else's AI was easy. The tank taunted, used damage abilities when over a certain percentage of mana (whatever it was), and that was about it. My two-hand warrior had about three skills, tops, that he just had to use whenever he had the rage (again, whatever it was). The mage would nuke with the same couple spells unless I needed to do something odd, like a blizzard / lightning storm combo, which only required limited input on my part. Simple, easy AI settings for everyone.

...except the rogue. Rogues require proper positioning, and have a lot of conditional skills that are hard to use effectively with the AI settings. So they sat on the sideline, for me.