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Not a doctor Roland00 Send a noteboard - 13/02/2019 04:56:57 AM

Hehe not a doctor, but part of me wants to take this comment literally.


I have tried every antidepressant known to medicine.

For I can list off 30+ antidepressants of 10 different classes of how they work in completely different ways. I am sure you have not tried literally every antidepressant known to medicine.

But that is not my job, not my duty or responsibility for I am not a medical expert.

And me being a friend "what I should really do" is I should advocate you finding a different doctor if your current one is not working well.

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Pivots back to the real conversation that you want to have


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Numerous studies have advocated the efficacy of Psilocybin Mushrooms in treating unresponsive depression. One or two experiences are all it takes to reverse a lifetime of suicidal thoughts. But our government insists on categorizing marijuana as a Schedule 1 drug. Much less psilocybin. So will I ever be able to try this treatment legally before aI die? Probably not.

I can't answer this question in a predictive fashion. I understand it and I sympathize.

I can't answer it with psilocybin, but there are other drugs out there. Furthermore the FDA is considering a Ketamine-based nasal drug called esketamine. It literally this very week voted 14-2 that the benefits outweigh the risks, and 15-2 that the safety profile metrics have been met and we are expecting the final voting outcome to happen sometime in March, probably March 4, 2019.

This drug has been especially good on the suicidal thought metrics even more so than most other forms of antidepressants. It is a really exciting agent.

But like I said earlier in my italics, you should look for another doctor and not a specific medicine, for finding the right medicine is systematic trial and error. All I can do is explain you have options, and furthermore the options are ever expanding.


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So Mookie I have no clue if this drug is the right drug for you. I also need to do some more reading up on it, reading stuff from Dr. Stephen Stahl and other things on google scholar. A cool thing Scientists in the medical community discovered in the 2018 timeframe is ketamine also impacts the endorphin / opiate system for if you give a person an opiate blocker in the test they are doing to understanding this agent that does multiple things (and some of those multiple things is why it treats depression) then Ketamine does not treat the depression.

I am not a replacement for a doctor by any long stretch. My point is the world is constantly changing and who knows what tomorrow will bring, day becomes night and night becomes day.

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Sidenote: Before I posted submit I noticed that the FDA just approved a 400+ Psilocybin research study for treatment resistant depression in the US and Europe to take place over the next 2 years (if all goes well it will be 12 to 18 months to do the actual study part but then followup, publishing, conferences, etc.) This approval was Oct 2018 and it was the Breakthrough Therapy Designation (introduced in 2012)

BTD is a designation for serious and life threatening disorders with an agent that has already showed significant benefit already that is different than the current treatment options, when you get BTD the FDA gets involved in your drug treatment study telling what they are looking for and you also get expedited priority through the drug review process compared to other drugs that are applicants. BTD does not mean this drug is a breakthrough in the common man meaning of the term, (yes language is silly and imprecise.)

Yet it will be at least 2+ years before the FDA approves Psilocybin for they need to do this 400+ study. Now when I say 2+ years in reality it will probably be closer to 5 years than 2 and maybe as much as 10 years for this 400+ person study is a Phase 2b study, they still need to do Phase 3 study afterwards.

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NSSP/I have tried every antidepressant known to medicine. - 13/02/2019 03:58:41 AM 506 Views
There's currently a trial underway. Maybe you can join? - 13/02/2019 04:51:12 AM 309 Views
They did more than that - 13/02/2019 05:01:03 AM 319 Views
Thank you for that. - 13/02/2019 05:04:06 AM 303 Views
Of course! - 13/02/2019 05:09:13 AM 290 Views
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5 classes of meds, will post more later. - 13/02/2019 07:28:29 AM 313 Views
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About the NMDA drugs... - 13/02/2019 05:55:26 AM 304 Views
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I saw that today - 06/03/2019 11:50:51 PM 282 Views

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