I think it's interesting that you use the term "relevant". I don't think that's necessarily the same thing as commenting on the human condition. You can do that through any medium. I was having a conversation about the game Skyrim with my husband regarding this very subject. I've heard you say that gaming is a waste of time. But one of the decisions I recently had to make in playing the game was reflective of real life decisions in that either way I chose I would not be on the "good" or "evil" side. Either way I chose, people I knew and cared for would have to suffer, all for no more than who they chose to follow to lead their country. Good games can incorporate these kinds of choices, where your character has to live with the consequences of their actions.
Same with books, really, of any kind. I know what you're talking about when you refer to those formulaic fantasy or even scifi books- believe me, I've seen a lot of those, too. But have you ever read The Hyperion Cantos by Dan Simmons? Deep, thought-provoking mixture of science fiction and fantasy that I think should be a classic. I know you've heard Anastasia and I both mention Wraeththu by Storm Constantine. Probably a bit flowery language for your taste, but I was really questioning my place in the universe and the nature of love at the end of that. Something as deceptively simple as Beagle's The Last Unicorn, even. It's a cliched question but is it better to have loved and lost? Doesn't it speak to you about what it truly means to be human? Even something like Ender's Game by Card. I wrote my tenth grade final on this book- it was the only book I enjoyed reading all year because it wasn't Sheakespeare or Camus or Kafka making me want to go off myself. I wrote another paper the next year comparing and contrasting the meaning of "fate" in Gaiman's Neverwhere and Wiesel's Night.
There is plenty of genre fiction with meaning out there. I could go on and on and I'm sure there are plenty others who could as well. These are just some examples of things that I've personally found meaning in. I don't mind if it's not your cup of tea, but I also want to make the point that a lot of what I read has intellectual value as well.